Tau local structure shields an amyloid-forming motif and controls aggregation propensity

Tauopathies are neurodegenerative diseases characterized by intracellular amyloid deposits of tau protein. Missense mutations in the tau gene (MAPT) correlate with aggregation propensity and cause dominantly inherited tauopathies, but their biophysical mechanism driving amyloid formation is poorly u...

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Detalles Bibliográficos
Autores principales: Chen, Dailu, Drombosky, Kenneth W., Hou, Zhiqiang, Sari, Levent, Kashmer, Omar M., Ryder, Bryan D., Perez, Valerie A., Woodard, DaNae R., Lin, Milo M., Diamond, Marc I., Joachimiak, Lukasz A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555816/
https://www.ncbi.nlm.nih.gov/pubmed/31175300
http://dx.doi.org/10.1038/s41467-019-10355-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555816/
https://www.ncbi.nlm.nih.gov/pubmed/31175300
http://dx.doi.org/10.1038/s41467-019-10355-1

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