H3.3K27M-induced chromatin changes drive ectopic replication through misregulation of the JNK pathway in C. elegans

Substitution of lysine 27 with methionine in histone H3.3 is a recently discovered driver mutation of pediatric high-grade gliomas. Mutant cells show decreased levels and altered distribution of H3K27 trimethylation (H3K27me3). How these chromatin changes are established genome-wide and lead to tumo...

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Detalles Bibliográficos
Autores principales: Delaney, Kamila, Strobino, Maude, Wenda, Joanna M., Pankowski, Andrzej, Steiner, Florian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555832/
https://www.ncbi.nlm.nih.gov/pubmed/31175278
http://dx.doi.org/10.1038/s41467-019-10404-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555832/
https://www.ncbi.nlm.nih.gov/pubmed/31175278
http://dx.doi.org/10.1038/s41467-019-10404-9

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