Cargando…

Exploration of interaction scoring criteria in the CANDO platform

OBJECTIVE: Ascertain the optimal interaction scoring criteria for the Computational Analysis of Novel Drug Opportunities (CANDO) platform for shotgun drug repurposing to improve benchmarking performance, thereby enabling more accurate prediction of novel therapeutic drug-indication pairs. RESULTS: W...

Descripción completa

Detalles Bibliográficos
Autores principales:	Falls, Zackary, Mangione, William, Schuler, James, Samudrala, Ram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Note
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555930/ https://www.ncbi.nlm.nih.gov/pubmed/31174591 http://dx.doi.org/10.1186/s13104-019-4356-3

Ejemplares similares

Optimal COVID-19 therapeutic candidate discovery using the CANDO platform
por: Mangione, William, et al.
Publicado: (2022)

Identifying Protein Features Responsible for Improved Drug Repurposing Accuracies Using the CANDO Platform: Implications for Drug Design
por: Mangione, William, et al.
Publicado: (2019)

Combating Ebola with Repurposed Therapeutics Using the CANDO Platform
por: Chopra, Gaurav, et al.
Publicado: (2016)

Fingerprinting CANDO: Increased Accuracy with Structure- and Ligand-Based Shotgun Drug Repurposing
por: Schuler, James, et al.
Publicado: (2019)

Multiscale Virtual Screening Optimization for Shotgun Drug Repurposing Using the CANDO Platform
por: Hudson, Matthew L., et al.
Publicado: (2021)

Effective holistic characterization of small molecule effects using heterogeneous biological networks
por: Mangione, William, et al.
Publicado: (2023)

Evaluating the performance of drug-repurposing technologies
por: Schuler, James, et al.
Publicado: (2022)

A Deep-Learning Proteomic-Scale Approach for Drug Design
por: Overhoff, Brennan, et al.
Publicado: (2021)

Shotgun drug repurposing biotechnology to tackle epidemics and pandemics
por: Mangione, William, et al.
Publicado: (2020)

Shotgun drug repurposing biotechnology to tackle epidemics and pandemics
por: Mangione, William, et al.
Publicado: (2020)

352 Computational methods for predicting drug combinations for targeting KRAS mutations relevant to non-small cell lung cancer
por: Bruggemann, Liana, et al.
Publicado: (2022)

Identifying Protein Features and Pathways Responsible for Toxicity Using Machine Learning and Tox21: Implications for Predictive Toxicology
por: Moukheiber, Lama, et al.
Publicado: (2022)

Multiscale Analysis and Validation of Effective Drug Combinations Targeting Driver KRAS Mutations in Non-Small Cell Lung Cancer
por: Bruggemann, Liana, et al.
Publicado: (2023)

Accurate Prediction of Inhibitor Binding to HIV-1 Protease Using CANDOCK
por: Falls, Zackary, et al.
Publicado: (2022)

Proteomic Network Analysis of Bronchoalveolar Lavage Fluid in Ex-Smokers to Discover Implicated Protein Targets and Novel Drug Treatments for Chronic Obstructive Pulmonary Disease
por: Mammen, Manoj J., et al.
Publicado: (2022)

Association of C>U RNA Editing with Human Disease Variants
por: MANDLOI, Sapan, et al.
Publicado: (2020)

Accelerated protein structure comparison using TM-score-GPU
por: Hung, Ling-Hong, et al.
Publicado: (2012)

A fluorescence-based, gain-of-signal, live cell system to evaluate SARS-CoV-2 main protease inhibition
por: Dey-Rao, Rama, et al.
Publicado: (2021)

The Role of C-to-U RNA Editing in Human Biodiversity
por: Van Norden, Melissa, et al.
Publicado: (2023)

Body composition and chemotherapy toxicity in women with early breast cancer (CANDO-3): protocol for an observational cohort study
por: Durkin, Kesta, et al.
Publicado: (2022)

fast_protein_cluster: parallel and optimized clustering of large-scale protein modeling data
por: Hung, Ling-Hong, et al.
Publicado: (2014)

GPU-Q-J, a fast method for calculating root mean square deviation (RMSD) after optimal superposition
por: Hung, Ling-Hong, et al.
Publicado: (2011)

Exploring the agreement between diagnostic criteria for IBS in primary care in Greece
por: Anastasiou, Foteini, et al.
Publicado: (2008)

Assessment of cytokines, microRNA and patient related outcome measures in conversion disorder/functional neurological disorder (CD/FND): The CANDO clinical feasibility study
por: van der Feltz-Cornelis, Christina, et al.
Publicado: (2021)

Multi-omics Visualization Platform: An extensible Galaxy plug-in for multi-omics data visualization and exploration
por: McGowan, Thomas, et al.
Publicado: (2020)

Interactive exploration of heterogeneous biological networks with Biomine Explorer
por: Podpečan, Vid, et al.
Publicado: (2019)

Combenefit: an interactive platform for the analysis and visualization of drug combinations
por: Di Veroli, Giovanni Y., et al.
Publicado: (2016)

LoCo: a novel main chain scoring function for protein structure prediction based on local coordinates
por: Moughon, Stewart E, et al.
Publicado: (2011)

Galaxy Portal: interacting with the galaxy platform through mobile devices
por: Børnich, Claus, et al.
Publicado: (2016)

A Systematic Review of Computational Drug Discovery, Development, and Repurposing for Ebola Virus Disease Treatment
por: Schuler, James, et al.
Publicado: (2017)

Vaa3D-x for cross-platform teravoxel-scale immersive exploration of multidimensional image data
por: Liang, Jiangshan, et al.
Publicado: (2023)

Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions
por: Kong, Weili, et al.
Publicado: (2019)

IPPC: an interactive platform for prostate cancer multi-omics data integration and analysis
por: Ye, Xiongjun, et al.
Publicado: (2021)

A knowledge-based scoring function based on residue triplets for protein structure prediction
por: Ngan, Shing-Chung, et al.
Publicado: (2006)

FungiExp: a user-friendly database and analysis platform for exploring fungal gene expression and alternative splicing
por: Liu, Jinding, et al.
Publicado: (2023)

Hive Panel Explorer: an interactive network visualization tool
por: Perez, Sarah E I, et al.
Publicado: (2020)

SmartR: an open-source platform for interactive visual analytics for translational research data
por: Herzinger, Sascha, et al.
Publicado: (2017)

ezQTL: A Web Platform for Interactive Visualization and Colocalization of QTLs and GWAS Loci
por: Zhang, Tongwu, et al.
Publicado: (2022)

Two cases of linear cutaneous depressions after botulinum toxin A
por: Nyckowski, Timothy, et al.
Publicado: (2022)

Exploring Strategies For Safe Motherhood
por: Manohar, P. Ram
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_bhi7ddcou9ig2jbvrtodmcps12