The Molecular Basis for Apolipoprotein E4 as the Major Risk Factor for Late-Onset Alzheimer's Disease

Apolipoprotein E4 (ApoE4) is one of three (E2, E3 and E4) human isoforms of an α-helical, 299-amino-acid protein. Homozygosity for the ε4 allele is the major genetic risk factor for developing late-onset Alzheimer's disease (AD). ApoE2, ApoE3 and ApoE4 differ at amino acid positions 112 and 158...

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Detalles Bibliográficos
Autores principales: Raulin, Ana-Caroline, Kraft, Lucas, Al-Hilaly, Youssra K., Xue, Wei-Feng, McGeehan, John E., Atack, John R., Serpell, Louise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556554/
https://www.ncbi.nlm.nih.gov/pubmed/31051176
http://dx.doi.org/10.1016/j.jmb.2019.04.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556554/
https://www.ncbi.nlm.nih.gov/pubmed/31051176
http://dx.doi.org/10.1016/j.jmb.2019.04.019

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