Pharmacokinetics of the SABRE agent 4,6-d(2)-nicotinamide and also nicotinamide in rats following oral and intravenous administration

To prepare the way for using the isotopically labelled SABRE hyperpolarized 4,6-d(2)-nicotinamide as an MRI agent in humans we have performed an in-vivo study to measure its pharmacokinetics in the plasma of healthy rats after intravenous and oral administration. Male Han Wistar rats were dosed with...

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Detalles Bibliográficos
Autores principales: Linnik, Inna V., Rayner, Peter J., Stow, Ruth A., Duckett, Simon B., Cheetham, Graham M.T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556870/
https://www.ncbi.nlm.nih.gov/pubmed/31077749
http://dx.doi.org/10.1016/j.ejps.2019.05.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556870/
https://www.ncbi.nlm.nih.gov/pubmed/31077749
http://dx.doi.org/10.1016/j.ejps.2019.05.004

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