Cargando…

Pan-cancer analysis identifies telomerase-associated signatures and cancer subtypes

BACKGROUND: Cancer cells become immortalized through telomere maintenance mechanisms, such as telomerase reverse transcriptase (TERT) activation. In addition to maintaining telomere length, TERT activates manifold cell survival signaling pathways. However, telomerase-associated gene signatures in ca...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Zhenhua, Wang, Weixu, Li, Feng, Songyang, Zhou, Feng, Xuyang, Xin, Changchang, Dai, Zhiming, Xiong, Yuanyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556968/ https://www.ncbi.nlm.nih.gov/pubmed/31179925 http://dx.doi.org/10.1186/s12943-019-1035-x

Ejemplares similares

TeloPIN: a database of telomeric proteins interaction network in mammalian cells
por: Luo, Zhenhua, et al.
Publicado: (2015)

Field cancerization profile-based prognosis signatures lead to more robust risk evaluation in hepatocellular carcinoma
por: Huang, Lu, et al.
Publicado: (2022)

Pan-cancer investigation of C-to-U editing reveals its important role in cancer development and new targets for cancer treatment
por: Guo, Mengbiao, et al.
Publicado: (2023)

CCSI: a database providing chromatin–chromatin spatial interaction information
por: Xie, Xiaowei, et al.
Publicado: (2016)

Genomic, epigenomic, and transcriptomic signatures for telomerase complex components: a pan‐cancer analysis
por: Wang, Jing, et al.
Publicado: (2022)

REIA: A database for cancer A-to-I RNA editing with interactive analysis
por: Zhu, Huimin, et al.
Publicado: (2022)

Pan-Cancer Analyses Identify the CTC1-STN1-TEN1 Complex as a Protective Factor and Predictive Biomarker for Immune Checkpoint Blockade in Cancer
por: Wang, Lishuai, et al.
Publicado: (2022)

Pan-Cancer Pyroptosis Analyses Identified Novel Immunology and Chemotherapy-Related Prognostic Signatures in Cancer Subtypes
por: Li, Canrong, et al.
Publicado: (2022)

Specific Tandem 3'UTR Patterns and Gene Expression Profiles in Mouse Thy1(+) Germline Stem Cells
por: Huang, Yan, et al.
Publicado: (2015)

Analysis of Lung Adenocarcinoma Subtypes Based on Immune Signatures Identifies Clinical Implications for Cancer Therapy
por: Xu, Feng, et al.
Publicado: (2020)

pgRNAFinder: a web-based tool to design distance independent paired-gRNA
por: Xiong, Yuanyan, et al.
Publicado: (2017)

Comprehensive Analysis of Large-Scale Transcriptomes from Multiple Cancer Types
por: Nong, Baoting, et al.
Publicado: (2021)

Telomerase-Independent Paths to Immortality in Predictable Cancer Subtypes
por: Durant, Stephen T
Publicado: (2012)

ForestSubtype: a cancer subtype identifying approach based on high-dimensional genomic data and a parallel random forest
por: Luo, Junwei, et al.
Publicado: (2023)

Three-dimensional and single-cell sequencing of liver cancer reveals comprehensive host-virus interactions in HBV infection
por: Guo, Mengbiao, et al.
Publicado: (2023)

Expression signature, prognosis value, and immune characteristics of Siglec-15 identified by pan-cancer analysis
por: Li, Baihui, et al.
Publicado: (2020)

APOBEC Alteration Contributes to Tumor Growth and Immune Escape in Pan-Cancer
por: Guo, Honghong, et al.
Publicado: (2022)

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase
por: Zhou, Zhifen, et al.
Publicado: (2022)

Pan-cancer onco-signatures reveal a novel mitochondrial subtype of luminal breast cancer with specific regulators
por: Simeone, Ines, et al.
Publicado: (2023)

A signature for pan-cancer prognosis based on neutrophil extracellular traps
por: Zhang, Yi, et al.
Publicado: (2022)

DNA signals at isoform promoters
por: Dai, Zhiming, et al.
Publicado: (2016)

Natural Product Library Screens Identify Sanguinarine Chloride as a Potent Inhibitor of Telomerase Expression and Activity
por: Yan, Siyu, et al.
Publicado: (2022)

Analysis of Tumor Microenvironment Heterogeneity among Breast Cancer Subtypes to Identify Subtype-Specific Signatures
por: Li, Ji, et al.
Publicado: (2022)

Telomerase gene identified.
Publicado: (1997)

Multi-omic signatures identify pan-cancer classes of tumors beyond tissue of origin
por: González-Reymúndez, Agustín, et al.
Publicado: (2020)

Expression characteristic, immune signature, and prognosis value of EFNA family identified by multi-omics integrative analysis in pan-cancer
por: Jiao, Zonglin, et al.
Publicado: (2022)

Distinct dosage compensations of ploidy-sensitive and -insensitive X chromosome genes during development and in diseases
por: Guo, Mengbiao, et al.
Publicado: (2023)

Identifying Robust Microbiota Signatures and Interpretable Rules to Distinguish Cancer Subtypes
por: Chen, Lei, et al.
Publicado: (2020)

Pan-cancer EMT-signature identifies RBM47 down-regulation during colorectal cancer progression
por: Rokavec, Matjaz, et al.
Publicado: (2017)

The expression signature of cancer‐associated KRAB‐ZNF factors identified in TCGA pan‐cancer transcriptomic data
por: Machnik, Marta, et al.
Publicado: (2019)

NELFE-Dependent MYC Signature Identifies a Unique Cancer Subtype in Hepatocellular Carcinoma
por: Dang, Hien, et al.
Publicado: (2019)

A gene signature based method for identifying subtypes and subtype-specific drivers in cancer with an application to medulloblastoma
por: Chen, Peikai, et al.
Publicado: (2013)

Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX
por: Hu, Yang, et al.
Publicado: (2016)

Genome-wide analysis of transcription factor binding sites and their characteristic DNA structures
por: Dai, Zhiming, et al.
Publicado: (2015)

A Comprehensive Pan-Cancer Analysis of the Potential Biological Functions and Prognosis Values of RICTOR
por: Sun, Ying, et al.
Publicado: (2023)

Pan-urologic cancer genomic subtypes that transcend tissue of origin
por: Chen, Fengju, et al.
Publicado: (2017)

Gastrointestinal adenocarcinoma analysis identifies promoter methylation-based cancer subtypes and signatures
por: Xiang, Renshen, et al.
Publicado: (2020)

Identifying the Signatures and Rules of Circulating Extracellular MicroRNA for Distinguishing Cancer Subtypes
por: Yuan, Fei, et al.
Publicado: (2021)

CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension
por: Wang, Huan, et al.
Publicado: (2023)

Development of cancer prognostic signature based on pan-cancer proteomics
por: Huang, Weiguo, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_lnch6nu4ngvr04i0j6leg44qfs