Elevated telomere dysfunction in cells containing the African-centric Pro47Ser cancer-risk variant of TP53

Subtelomeric transcription and chromatin can have a significant impact on telomere repeat maintenance and chromosome stability. We have previously found that tumor suppressor protein p53 (TP53) can bind to retrotransposon-like elements in a majority of human subtelomeres to regulate TERRA transcript...

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Detalles Bibliográficos
Autores principales: Tutton, Stephen, Deng, Zhong, Gulve, Nitish, Vladimirova, Olga, Beishline, Kate, Wiedmer, Andreas, Murphy, Maureen, Lieberman, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557208/
https://www.ncbi.nlm.nih.gov/pubmed/31217894
http://dx.doi.org/10.18632/oncotarget.26980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557208/
https://www.ncbi.nlm.nih.gov/pubmed/31217894
http://dx.doi.org/10.18632/oncotarget.26980

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