Engineered bacteriophages for treatment of a patient with a disseminated drug resistant Mycobacterium abscessus

A 15-year-old cystic fibrosis patient with a disseminated Mycobacterium abscessus infection was treated with a three-phage cocktail following bilateral lung transplantation. Effective lytic phage derivatives that efficiently kill the infectious M. abscessus strain were developed by genome engineerin...

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Detalles Bibliográficos
Autores principales: Dedrick, Rebekah M., Guerrero-Bustamante, Carlos A., Garlena, Rebecca A., Russell, Daniel A., Ford, Katrina, Harris, Kathryn, Gilmour, Kimberly C., Soothill, James, Jacobs-Sera, Deborah, Schooley, Robert T., Hatfull, Graham F., Spencer, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557439/
https://www.ncbi.nlm.nih.gov/pubmed/31068712
http://dx.doi.org/10.1038/s41591-019-0437-z
Descripción
Sumario:A 15-year-old cystic fibrosis patient with a disseminated Mycobacterium abscessus infection was treated with a three-phage cocktail following bilateral lung transplantation. Effective lytic phage derivatives that efficiently kill the infectious M. abscessus strain were developed by genome engineering and forward genetics. Intravenous phage treatment was well tolerated and associated with objective clinical improvement including sternal wound closure, improved liver function, and substantial resolution of infected skin nodules.

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