Engineered bacteriophages for treatment of a patient with a disseminated drug resistant Mycobacterium abscessus

A 15-year-old cystic fibrosis patient with a disseminated Mycobacterium abscessus infection was treated with a three-phage cocktail following bilateral lung transplantation. Effective lytic phage derivatives that efficiently kill the infectious M. abscessus strain were developed by genome engineerin...

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Autores principales: Dedrick, Rebekah M., Guerrero-Bustamante, Carlos A., Garlena, Rebecca A., Russell, Daniel A., Ford, Katrina, Harris, Kathryn, Gilmour, Kimberly C., Soothill, James, Jacobs-Sera, Deborah, Schooley, Robert T., Hatfull, Graham F., Spencer, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557439/
https://www.ncbi.nlm.nih.gov/pubmed/31068712
http://dx.doi.org/10.1038/s41591-019-0437-z
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author Dedrick, Rebekah M.
Guerrero-Bustamante, Carlos A.
Garlena, Rebecca A.
Russell, Daniel A.
Ford, Katrina
Harris, Kathryn
Gilmour, Kimberly C.
Soothill, James
Jacobs-Sera, Deborah
Schooley, Robert T.
Hatfull, Graham F.
Spencer, Helen
author_facet Dedrick, Rebekah M.
Guerrero-Bustamante, Carlos A.
Garlena, Rebecca A.
Russell, Daniel A.
Ford, Katrina
Harris, Kathryn
Gilmour, Kimberly C.
Soothill, James
Jacobs-Sera, Deborah
Schooley, Robert T.
Hatfull, Graham F.
Spencer, Helen
author_sort Dedrick, Rebekah M.
collection PubMed
description A 15-year-old cystic fibrosis patient with a disseminated Mycobacterium abscessus infection was treated with a three-phage cocktail following bilateral lung transplantation. Effective lytic phage derivatives that efficiently kill the infectious M. abscessus strain were developed by genome engineering and forward genetics. Intravenous phage treatment was well tolerated and associated with objective clinical improvement including sternal wound closure, improved liver function, and substantial resolution of infected skin nodules.
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spelling pubmed-65574392019-11-08 Engineered bacteriophages for treatment of a patient with a disseminated drug resistant Mycobacterium abscessus Dedrick, Rebekah M. Guerrero-Bustamante, Carlos A. Garlena, Rebecca A. Russell, Daniel A. Ford, Katrina Harris, Kathryn Gilmour, Kimberly C. Soothill, James Jacobs-Sera, Deborah Schooley, Robert T. Hatfull, Graham F. Spencer, Helen Nat Med Article A 15-year-old cystic fibrosis patient with a disseminated Mycobacterium abscessus infection was treated with a three-phage cocktail following bilateral lung transplantation. Effective lytic phage derivatives that efficiently kill the infectious M. abscessus strain were developed by genome engineering and forward genetics. Intravenous phage treatment was well tolerated and associated with objective clinical improvement including sternal wound closure, improved liver function, and substantial resolution of infected skin nodules. 2019-05-08 2019-05 /pmc/articles/PMC6557439/ /pubmed/31068712 http://dx.doi.org/10.1038/s41591-019-0437-z Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Dedrick, Rebekah M.
Guerrero-Bustamante, Carlos A.
Garlena, Rebecca A.
Russell, Daniel A.
Ford, Katrina
Harris, Kathryn
Gilmour, Kimberly C.
Soothill, James
Jacobs-Sera, Deborah
Schooley, Robert T.
Hatfull, Graham F.
Spencer, Helen
Engineered bacteriophages for treatment of a patient with a disseminated drug resistant Mycobacterium abscessus
title Engineered bacteriophages for treatment of a patient with a disseminated drug resistant Mycobacterium abscessus
title_full Engineered bacteriophages for treatment of a patient with a disseminated drug resistant Mycobacterium abscessus
title_fullStr Engineered bacteriophages for treatment of a patient with a disseminated drug resistant Mycobacterium abscessus
title_full_unstemmed Engineered bacteriophages for treatment of a patient with a disseminated drug resistant Mycobacterium abscessus
title_short Engineered bacteriophages for treatment of a patient with a disseminated drug resistant Mycobacterium abscessus
title_sort engineered bacteriophages for treatment of a patient with a disseminated drug resistant mycobacterium abscessus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557439/
https://www.ncbi.nlm.nih.gov/pubmed/31068712
http://dx.doi.org/10.1038/s41591-019-0437-z
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