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Crystal structures of Moorella thermoacetica cyanuric acid hydrolase reveal conformational flexibility and asymmetry important for catalysis

An ancient enzyme family responsible for the catabolism of the prebiotic chemical cyanuric acid (1,3,5-triazine-2,4,6-triol) was recently discovered and is undergoing proliferation in the modern world due to industrial synthesis and dissemination of 1,3,5-triazine compounds. Cyanuric acid has a high...

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Detalles Bibliográficos
Autores principales: Shi, Ke, Cho, Seunghee, Aukema, Kelly G., Lee, Thomas, Bera, Asim K., Seffernick, Jennifer L., Wackett, Lawrence P., Aihara, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557486/
https://www.ncbi.nlm.nih.gov/pubmed/31181074
http://dx.doi.org/10.1371/journal.pone.0216979