Epigenomic profiling of newborns with isolated orofacial clefts reveals widespread DNA methylation changes and implicates metastable epiallele regions in disease risk

Cleft lip with or without cleft palate (CL/P) is a common human birth defect whose etiologies remain largely unknown. Several studies have demonstrated that periconceptional supplementation of folic acid can reduce risk of CL/P in offspring. In this study, we tested the hypothesis that the preventiv...

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Detalles Bibliográficos
Autores principales: Gonseth, Semira, Shaw, Gary M., Roy, Ritu, Segal, Mark R., Asrani, Kripa, Rine, Jasper, Wiemels, Joseph, Marini, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557558/
https://www.ncbi.nlm.nih.gov/pubmed/30870065
http://dx.doi.org/10.1080/15592294.2019.1581591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557558/
https://www.ncbi.nlm.nih.gov/pubmed/30870065
http://dx.doi.org/10.1080/15592294.2019.1581591

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