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The chromatin remodeling protein Lsh alters nucleosome occupancy at putative enhancers and modulates binding of lineage specific transcription factors

Dynamic regulation of chromatin accessibility is a key feature of cellular differentiation during embryogenesis, but the precise factors that control access to chromatin remain largely unknown. Lsh/HELLS is critical for normal development and mutations of Lsh in human cause the ICF (Immune deficienc...

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Detalles Bibliográficos
Autores principales: Ren, Jianke, Finney, Richard, Ni, Kai, Cam, Maggie, Muegge, Kathrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557562/
https://www.ncbi.nlm.nih.gov/pubmed/30861354
http://dx.doi.org/10.1080/15592294.2019.1582275