Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

Regulated exocytosis establishes a narrow fusion pore as initial aqueous connection to the extracellular space, through which small transmitter molecules such as ATP can exit. Co-release of polypeptides and hormones like insulin requires further expansion of the pore. There is evidence that pore exp...

Descripción completa

Detalles Bibliográficos
Autores principales: Guček, Alenka, Gandasi, Nikhil R, Omar-Hmeadi, Muhmmad, Bakke, Marit, Døskeland, Stein O, Tengholm, Anders, Barg, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557626/
https://www.ncbi.nlm.nih.gov/pubmed/31099751
http://dx.doi.org/10.7554/eLife.41711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557626/
https://www.ncbi.nlm.nih.gov/pubmed/31099751
http://dx.doi.org/10.7554/eLife.41711

Ejemplares similares