Single cell, super-resolution imaging reveals an acid pH-dependent conformational switch in SsrB regulates SPI-2

After Salmonella is phagocytosed, it resides in an acidic vacuole. Its cytoplasm acidifies to pH 5.6; acidification activates pathogenicity island 2 (SPI-2). SPI-2 encodes a type three secretion system whose effectors modify the vacuole, driving endosomal tubulation. Using super-resolution imaging i...

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Detalles Bibliográficos
Autores principales: Liew, Andrew Tze Fui, Foo, Yong Hwee, Gao, Yunfeng, Zangoui, Parisa, Singh, Moirangthem Kiran, Gulvady, Ranjit, Kenney, Linda J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557628/
https://www.ncbi.nlm.nih.gov/pubmed/31033442
http://dx.doi.org/10.7554/eLife.45311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557628/
https://www.ncbi.nlm.nih.gov/pubmed/31033442
http://dx.doi.org/10.7554/eLife.45311

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