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Postnatal N-acetylcysteine administration rescues impaired social behaviors and neurogenesis in Slc13a4 haploinsufficient mice

BACKGROUND: Sulfate availability is crucial for the sulfonation of brain extracellular matrix constituents, membrane phospholipids, neurosteroids, and neurotransmitters. Observations from humans and mouse models suggest dysregulated sulfate levels may be associated with neurodevelopmental disorders,...

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Detalles Bibliográficos
Autores principales: Zhang, Zhe, Dawson, Paul Anthony, Piper, Michael, Simmons, David Gordon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557756/
https://www.ncbi.nlm.nih.gov/pubmed/30956169
http://dx.doi.org/10.1016/j.ebiom.2019.03.081