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Beyond multidrug resistance: Leveraging rare variants with machine and statistical learning models in Mycobacterium tuberculosis resistance prediction
BACKGROUND: The diagnosis of multidrug resistant and extensively drug resistant tuberculosis is a global health priority. Whole genome sequencing of clinical Mycobacterium tuberculosis isolates promises to circumvent the long wait times and limited scope of conventional phenotypic antimicrobial susc...
Autores principales: | Chen, Michael L., Doddi, Akshith, Royer, Jimmy, Freschi, Luca, Schito, Marco, Ezewudo, Matthew, Kohane, Isaac S., Beam, Andrew, Farhat, Maha |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557804/ https://www.ncbi.nlm.nih.gov/pubmed/31047860 http://dx.doi.org/10.1016/j.ebiom.2019.04.016 |
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