GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson’s Disease

While GM1 may interact with α-synuclein in vitro to inhibit aggregation, the ability of GM1 to protect against α-synuclein toxicity in vivo has not been investigated. We used targeted adeno-associated viral vector (AAV) overexpression of human mutant α-synuclein (A53T) in the rat substantia nigra (S...

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Detalles Bibliográficos
Autores principales: Schneider, Jay S., Aras, Radha, Williams, Courtney K., Koprich, James B., Brotchie, Jonathan M., Singh, Vikrant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557812/
https://www.ncbi.nlm.nih.gov/pubmed/31182727
http://dx.doi.org/10.1038/s41598-019-42847-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557812/
https://www.ncbi.nlm.nih.gov/pubmed/31182727
http://dx.doi.org/10.1038/s41598-019-42847-x

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