Insight into the structural stability of wild-type and histidine mutants in Pin1 by experimental and computational methods

Pin1, a polypeptide proline isomerase parvulin, plays a key role in Alzheimer’s disease (AD), common tumors and cancers. Two conservative histidine residues, His59 and His157, are important for maintaining the stability of the PPIase domain. Hence multiple spectral and computational techniques were...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Wang, Xi, Lei, Xiong, Xiuhong, Li, Xue, Zhang, Qingyan, Yang, Wentao, Du, Linfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557836/
https://www.ncbi.nlm.nih.gov/pubmed/31182777
http://dx.doi.org/10.1038/s41598-019-44926-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557836/
https://www.ncbi.nlm.nih.gov/pubmed/31182777
http://dx.doi.org/10.1038/s41598-019-44926-5

Ejemplares similares