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Insight into the structural stability of wild-type and histidine mutants in Pin1 by experimental and computational methods
Pin1, a polypeptide proline isomerase parvulin, plays a key role in Alzheimer’s disease (AD), common tumors and cancers. Two conservative histidine residues, His59 and His157, are important for maintaining the stability of the PPIase domain. Hence multiple spectral and computational techniques were...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557836/ https://www.ncbi.nlm.nih.gov/pubmed/31182777 http://dx.doi.org/10.1038/s41598-019-44926-5 |