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The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease

Microglia, the brain-resident myeloid cells, are strongly implicated in Alzheimer's disease (AD) pathogenesis by human genetics. However, the mechanisms by which microglial gene expression is regulated in a region-specific manner over the course of normal aging and in neurodegenerative disease...

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Detalles Bibliográficos
Autores principales: Bonham, Luke W., Sirkis, Daniel W., Yokoyama, Jennifer S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557985/
https://www.ncbi.nlm.nih.gov/pubmed/31214167
http://dx.doi.org/10.3389/fimmu.2019.01170