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A symmetric toggle switch explains the onset of random X inactivation in different mammals

Gene-regulatory networks control establishment and maintenance of alternative gene expression states during development. A particular challenge is the acquisition of opposing states by two copies of the same gene, as it is the case in mammals for Xist at the onset of random X-chromosome inactivation...

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Detalles Bibliográficos
Autores principales: Mutzel, Verena, Okamoto, Ikuhiro, Dunkel, Ilona, Saitou, Mitinori, Giorgetti, Luca, Heard, Edith, Schulz, Edda G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558282/
https://www.ncbi.nlm.nih.gov/pubmed/30962582
http://dx.doi.org/10.1038/s41594-019-0214-1