Attenuation of Human Respiratory Viruses by Synonymous Genome Recoding

Using computer algorithms and commercial DNA synthesis, one or more ORFs of a microbial pathogen such as a virus can be recoded and deoptimized by several strategies that may involve the introduction of up to thousands of nucleotide (nt) changes without affecting amino acid (aa) coding. The synonymo...

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Detalles Bibliográficos
Autores principales: Le Nouën, Cyril, Collins, Peter L., Buchholz, Ursula J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558635/
https://www.ncbi.nlm.nih.gov/pubmed/31231383
http://dx.doi.org/10.3389/fimmu.2019.01250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558635/
https://www.ncbi.nlm.nih.gov/pubmed/31231383
http://dx.doi.org/10.3389/fimmu.2019.01250

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