Cargando…
Attenuation of Human Respiratory Viruses by Synonymous Genome Recoding
Using computer algorithms and commercial DNA synthesis, one or more ORFs of a microbial pathogen such as a virus can be recoded and deoptimized by several strategies that may involve the introduction of up to thousands of nucleotide (nt) changes without affecting amino acid (aa) coding. The synonymo...
Autores principales: | Le Nouën, Cyril, Collins, Peter L., Buchholz, Ursula J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558635/ https://www.ncbi.nlm.nih.gov/pubmed/31231383 http://dx.doi.org/10.3389/fimmu.2019.01250 |
Ejemplares similares
-
Impact of Synonymous Genome Recoding on the HIV Life Cycle
por: Jordan-Paiz, Ana, et al.
Publicado: (2021) -
Reversion mutations in phosphoprotein P of a codon-pair-deoptimized human respiratory syncytial virus confer increased transcription, immunogenicity, and genetic stability without loss of attenuation
por: Chen, Jessica W., et al.
Publicado: (2021) -
Respiratory Syncytial Virus Interferon Antagonist NS1 Protein Suppresses and Skews the Human T Lymphocyte Response
por: Munir, Shirin, et al.
Publicado: (2011) -
Low CCR7-Mediated Migration of Human Monocyte Derived Dendritic Cells in Response to Human Respiratory Syncytial Virus and Human Metapneumovirus
por: Le Nouën, Cyril, et al.
Publicado: (2011) -
Effects of Human Respiratory Syncytial Virus, Metapneumovirus, Parainfluenza Virus 3 and Influenza Virus on CD4+ T Cell Activation by Dendritic Cells
por: Le Nouën, Cyril, et al.
Publicado: (2010)