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Synthesis of Substituted Benzaldehydes via a Two-Step, One-Pot Reduction/Cross-Coupling Procedure

[Image: see text] The synthesis of functionalized (benz)aldehydes, via a two-step, one-pot procedure, is presented. The method employs a stable aluminum hemiaminal as a tetrahedral intermediate, protecting a latent aldehyde, making it suitable for subsequent cross-coupling with (strong nucleophilic)...

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Detalles Bibliográficos
Autores principales: Heijnen, Dorus, Helbert, Hugo, Luurtsema, Gert, Elsinga, Philip H., Feringa, Ben L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558639/
https://www.ncbi.nlm.nih.gov/pubmed/31083960
http://dx.doi.org/10.1021/acs.orglett.9b01274