Cargando…

Comprehensive genomic characterization of breast tumors with BRCA1 and BRCA2 mutations

BACKGROUND: Germline mutations in the BRCA1 and BRCA2 genes predispose carriers to breast and ovarian cancer, and there remains a need to identify the specific genomic mechanisms by which cancer evolves in these patients. Here we present a systematic genomic analysis of breast tumors with BRCA1 and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lal, Avantika, Ramazzotti, Daniele, Weng, Ziming, Liu, Keli, Ford, James M., Sidow, Arend
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558765/ https://www.ncbi.nlm.nih.gov/pubmed/31182087 http://dx.doi.org/10.1186/s12920-019-0545-0

Ejemplares similares

De novo mutational signature discovery in tumor genomes using SparseSignatures
por: Lal, Avantika, et al.
Publicado: (2021)

Multi-omic tumor data reveal diversity of molecular mechanisms that correlate with survival
por: Ramazzotti, Daniele, et al.
Publicado: (2018)

SparseSignatures: An R package using LASSO-regularized non-negative matrix factorization to identify mutational signatures from human tumor samples
por: Mella, Lorenzo, et al.
Publicado: (2022)

A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer
por: Karami, Fatemeh, et al.
Publicado: (2013)

Comprehensive Analysis of BRCA1, BRCA2 and TP53 Germline Mutation and Tumor Characterization: A Portrait of Early-Onset Breast Cancer in Brazil
por: Carraro, Dirce Maria, et al.
Publicado: (2013)

Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
por: Glodzik, Dominik, et al.
Publicado: (2020)

Breast tumor characteristics of BRCA1 and BRCA2 gene mutation carriers on MRI
por: Veltman, J., et al.
Publicado: (2008)

Predominance of BRCA2 Mutation and Estrogen Receptor Positivity in Unselected Breast Cancer with BRCA1 or BRCA2 Mutation
por: Pujol, Pascal, et al.
Publicado: (2022)

Screening BRCA1 and BRCA2 Mutation Carriers for Breast Cancer
por: Warner, Ellen
Publicado: (2018)

Mutation Analysis of BRCA1 and BRCA2 in Italian Hereditary and Sporadic Forms of Breast and Ovarian Cancers: Tumor Genotype-Phenotype Correlation in Breast Cancer BRCA-Mutation Carriers
por: Cipollini, G., et al.
Publicado: (1999)

Aquila enables reference-assisted diploid personal genome assembly and comprehensive variant detection based on linked reads
por: Zhou, Xin, et al.
Publicado: (2021)

Beyond Breast and Ovarian Cancers: PARP Inhibitors for BRCA Mutation-Associated and BRCA-Like Solid Tumors
por: O’Sullivan, Ciara C., et al.
Publicado: (2014)

Performance of multiplicom's BRCA MASTR Dx kit on the detection of BRCA1 and BRCA2 mutations in fresh frozen ovarian and breast tumor samples
por: Badoer, Cindy, et al.
Publicado: (2016)

Mutations of the BRCA1 and BRCA2 genes in patients with bilateral breast cancer
por: Steinmann, D, et al.
Publicado: (2001)

Variation in breast cancer risk in BRCA1 and BRCA2 mutation carriers
por: Rebbeck, Timothy R, et al.
Publicado: (2008)

Breast cancer prevention in women with a BRCA1 or BRCA2 mutation
por: Metcalfe, Kelly A, et al.
Publicado: (2007)

Risks of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers
por: Ahmed, M, et al.
Publicado: (2010)

Predictors of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers
por: Metcalfe, K, et al.
Publicado: (2011)

Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
por: Kotsopoulos, Joanne, et al.
Publicado: (2012)

Prevalence of BRCA1 and BRCA2 Mutations in Korean Breast Cancer Patients
por: Ahn, Sei Hyun, et al.
Publicado: (2004)

Distribution of BRCA1 and BRCA2 Mutations in Asian Patients with Breast Cancer
por: Kim, Haeyoung, et al.
Publicado: (2013)

The importance of BRCA1 and BRCA2 genes mutations in breast cancer development
por: Mehrgou, Amir, et al.
Publicado: (2016)

Transcriptome Patterns of BRCA1- and BRCA2- Mutated Breast and Ovarian Cancers
por: Arakelyan, Arsen, et al.
Publicado: (2021)

Looking for BRCA1 and BRCA2 mutations in Asian women with breast cancer
por: Narod, Steven A.
Publicado: (2023)

BRCA1 and BRCA2 in breast cancer families from Wales: moderate mutation frequency and two recurrent mutations in BRCA1.
por: Lancaster, J. M., et al.
Publicado: (1998)

Novel BRCA1 and BRCA2 genomic rearrangements in Southern Chinese breast/ovarian cancer patients
por: Kwong, Ava, et al.
Publicado: (2012)

BRCA Mutations and Breast Cancer Prevention
por: Kotsopoulos, Joanne
Publicado: (2018)

Tumor Mutation Burden Forecasts Outcome in Ovarian Cancer with BRCA1 or BRCA2 Mutations
por: Birkbak, Nicolai Juul, et al.
Publicado: (2013)

De novo diploid genome assembly for genome-wide structural variant detection
por: Zhang, Lu, et al.
Publicado: (2019)

Presymptomatic breast cancer in Egypt: role of BRCA1 and BRCA2 tumor suppressor genes mutations detection
por: Ibrahim, Safinaz S, et al.
Publicado: (2010)

Molecular Trajectory of BRCA1 and BRCA2 Mutations
por: Hatano, Yuichiro, et al.
Publicado: (2020)

Prevalence of BRCA1 and BRCA2 Jewish mutations in Spanish breast cancer patients
por: Díez, O, et al.
Publicado: (1999)

Parity and breast cancer risk among BRCA1 and BRCA2 mutation carriers
por: Antoniou, Antonis C, et al.
Publicado: (2006)

Prevalance of BRCA1 and BRCA2 mutations in familial breast cancer patients in Lebanon
por: Jalkh, Nadine, et al.
Publicado: (2012)

Contribution of BRCA1 and BRCA2 Germline Mutations to Early Algerian Breast Cancer
por: Henouda, Sarra, et al.
Publicado: (2016)

Mutational spectrum in breast cancer associated BRCA1 and BRCA2 genes in Colombia
por: Briceño-Balcázar, Ignacio, et al.
Publicado: (2017)

Plasma osteoprotegerin and breast cancer risk in BRCA1 and BRCA2 mutation carriers
por: Odén, Lovisa, et al.
Publicado: (2016)

BRCA promoter methylation in sporadic versus BRCA germline mutation-related breast cancers
por: Vos, Shoko, et al.
Publicado: (2017)

Mutational analysis of BRCA1 and BRCA2 in northwest Chinese breast cancer patients
por: Wang, Ting, et al.
Publicado: (2019)

Clinicopathological and ultrasound characteristics of breast cancer in BRCA1 and BRCA2 mutation carriers
por: Ikejima, Kengo, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_39ki4fi6dvs3l56a2al799meup