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Non-contact co-culture with human vascular endothelial cells promotes epithelial-to-mesenchymal transition of cervical cancer SiHa cells by activating the NOTCH1/LOX/SNAIL pathway

BACKGROUND: The aim of this study was to investigate the effect of human umbilical vein endothelial cells on epithelial-to-mesenchymal transition of the cervical cancer cell line SiHa by studying the Notch1/lysyl oxidase (LOX)/SNAIL1 pathway. METHODS: Monocultures of SiHa cells, SiHa cells containin...

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Detalles Bibliográficos
Autores principales: Ou, Jinghua, Guan, Defeng, Yang, Yongxiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558906/
https://www.ncbi.nlm.nih.gov/pubmed/31205475
http://dx.doi.org/10.1186/s11658-019-0163-z