Designing a chemical inhibitor of the AAA protein spastin using active site mutations

Spastin is a microtubule-severing AAA (ATPases associated with diverse cellular activities) protein needed for cell division and intracellular vesicle transport. Currently, we lack chemical inhibitors to probe spastin function in such dynamic cellular processes. To design a chemical inhibitor of spa...

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Detalles Bibliográficos
Autores principales: Cupido, Tommaso, Pisa, Rudolf, Kelley, Megan E., Kapoor, Tarun M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558985/
https://www.ncbi.nlm.nih.gov/pubmed/30778202
http://dx.doi.org/10.1038/s41589-019-0225-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558985/
https://www.ncbi.nlm.nih.gov/pubmed/30778202
http://dx.doi.org/10.1038/s41589-019-0225-6

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