Network Biology Identifies Novel Regulators of CFTR Trafficking and Membrane Stability

In cystic fibrosis, the most common disease-causing mutation is F508del, which causes not only intracellular retention and degradation of CFTR, but also defective channel gating and decreased membrane stability of the small amount that reaches the plasma membrane (PM). Thus, pharmacological correcti...

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Detalles Bibliográficos
Autores principales: Loureiro, Cláudia Almeida, Santos, João D., Matos, Ana Margarida, Jordan, Peter, Matos, Paulo, Farinha, Carlos M., Pinto, Francisco R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559121/
https://www.ncbi.nlm.nih.gov/pubmed/31231217
http://dx.doi.org/10.3389/fphar.2019.00619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559121/
https://www.ncbi.nlm.nih.gov/pubmed/31231217
http://dx.doi.org/10.3389/fphar.2019.00619

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