Preclinical in vivo characterization of lemborexant (E2006), a novel dual orexin receptor antagonist for sleep/wake regulation

STUDY OBJECTIVES: To present results from in vivo studies underlying the preclinical development of lemborexant (E2006), a novel dual orexin (hypocretin) receptor antagonist for sleep/wake regulation. METHODS: Rodent (wild-type rats and wild-type and orexin neuron-deficient [orexin/ataxin-3 Tg/+] mi...

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Detalles Bibliográficos
Autores principales: Beuckmann, Carsten Theodor, Ueno, Takashi, Nakagawa, Makoto, Suzuki, Michiyuki, Akasofu, Shigeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Insomnia and Psychiatric Disorders
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559177/
https://www.ncbi.nlm.nih.gov/pubmed/30923834
http://dx.doi.org/10.1093/sleep/zsz076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559177/
https://www.ncbi.nlm.nih.gov/pubmed/30923834
http://dx.doi.org/10.1093/sleep/zsz076

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