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Aminosalicylic acid reduces ER stress and Schwann cell death induced by MPZ mutations

Mutations in myelin protein zero (MPZ) cause inherited peripheral neuropathies, including Charcot-Marie-Tooth disease (CMT) and Dejerine-Sottas neuropathy. Mutant MPZ proteins have previously been reported to cause CMT via enhanced endoplasmic reticulum (ER) stress and Schwann cell (SC) death, altho...

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Detalles Bibliográficos
Autores principales: Chang, Eun Hyuk, Mo, Won Min, Doo, Hyun Myung, Lee, Ji-Su, Park, Hwan Tae, Choi, Byung-Ok, Hong, Young Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559330/
https://www.ncbi.nlm.nih.gov/pubmed/31059078
http://dx.doi.org/10.3892/ijmm.2019.4178