A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses

Rhino- and enteroviruses are important human pathogens, against which no antivirals are available. The best-studied inhibitors are “capsid binders” that fit in a hydrophobic pocket of the viral capsid. Employing a new class of entero-/rhinovirus inhibitors and by means of cryo–electron microscopy (E...

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Detalles Bibliográficos
Autores principales: Abdelnabi, Rana, Geraets, James A., Ma, Yipeng, Mirabelli, Carmen, Flatt, Justin W., Domanska, Aušra, Delang, Leen, Jochmans, Dirk, Kumar, Timiri Ajay, Jayaprakash, Venkatesan, Sinha, Barij Nayan, Leyssen, Pieter, Butcher, Sarah J., Neyts, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559632/
https://www.ncbi.nlm.nih.gov/pubmed/31185007
http://dx.doi.org/10.1371/journal.pbio.3000281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559632/
https://www.ncbi.nlm.nih.gov/pubmed/31185007
http://dx.doi.org/10.1371/journal.pbio.3000281

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