Examining the effects of the histone methyltransferase inhibitor BIX-01294 on histone modifications and gene expression in both a clinical population and mouse models

Schizophrenia has been consistently characterized by abnormal patterns of gene down-regulation, increased restrictive chromatin assemblies, and reduced transcriptional activity. Histone methyltransferase (HMT) mRNA and H3K9me2 levels are elevated in postmortem brain and peripheral blood cells of per...

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Detalles Bibliográficos
Autores principales: Chase, Kayla A., Feiner, Benjamin, Ramaker, Marcia J., Hu, Edward, Rosen, Cherise, Sharma, Rajiv P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559633/
https://www.ncbi.nlm.nih.gov/pubmed/31185023
http://dx.doi.org/10.1371/journal.pone.0216463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559633/
https://www.ncbi.nlm.nih.gov/pubmed/31185023
http://dx.doi.org/10.1371/journal.pone.0216463

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