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Examining the effects of the histone methyltransferase inhibitor BIX-01294 on histone modifications and gene expression in both a clinical population and mouse models
Schizophrenia has been consistently characterized by abnormal patterns of gene down-regulation, increased restrictive chromatin assemblies, and reduced transcriptional activity. Histone methyltransferase (HMT) mRNA and H3K9me2 levels are elevated in postmortem brain and peripheral blood cells of per...
Autores principales: | Chase, Kayla A., Feiner, Benjamin, Ramaker, Marcia J., Hu, Edward, Rosen, Cherise, Sharma, Rajiv P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559633/ https://www.ncbi.nlm.nih.gov/pubmed/31185023 http://dx.doi.org/10.1371/journal.pone.0216463 |
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