The interplay at the replisome mitigates the impact of oxidative damage on the genetic integrity of hyperthermophilic Archaea

8-oxodeoxyguanosine (8-oxodG), a major oxidised base modification, has been investigated to study its impact on DNA replication in hyperthermophilic Archaea. Here we show that 8-oxodG is formed in the genome of growing cells, with elevated levels following exposure to oxidative stress. Functional ch...

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Detalles Bibliográficos
Autores principales: Killelea, Tom, Palud, Adeline, Akcha, Farida, Lemor, Mélanie, L'haridon, Stephane, Godfroy, Anne, Henneke, Ghislaine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559790/
https://www.ncbi.nlm.nih.gov/pubmed/31184586
http://dx.doi.org/10.7554/eLife.45320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559790/
https://www.ncbi.nlm.nih.gov/pubmed/31184586
http://dx.doi.org/10.7554/eLife.45320

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