A critical evaluation of the approaches to targeted protein degradation for drug discovery

There is a great deal of excitement around the concept of targeting proteins for degradation as an alternative to conventional inhibitory small molecules and antibodies. Protein degradation can be undertaken by bifunctional molecules that bind the target for ubiquitin mediated degradation by complex...

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Detalles Bibliográficos
Autores principales: Chopra, Rajesh, Sadok, Amine, Collins, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559946/
https://www.ncbi.nlm.nih.gov/pubmed/31200859
http://dx.doi.org/10.1016/j.ddtec.2019.02.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559946/
https://www.ncbi.nlm.nih.gov/pubmed/31200859
http://dx.doi.org/10.1016/j.ddtec.2019.02.002

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