Cargando…
Glucose controls glucagon secretion by directly modulating cAMP in alpha cells
AIMS/HYPOTHESIS: Glucagon is critical for normal glucose homeostasis and aberrant secretion of the hormone aggravates dysregulated glucose control in diabetes. However, the mechanisms by which glucose controls glucagon secretion from pancreatic alpha cells remain elusive. The aim of this study was t...
Autores principales: | Yu, Qian, Shuai, Hongyan, Ahooghalandari, Parvin, Gylfe, Erik, Tengholm, Anders |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560012/ https://www.ncbi.nlm.nih.gov/pubmed/30953108 http://dx.doi.org/10.1007/s00125-019-4857-6 |
Ejemplares similares
-
Glucose‐induced cAMP elevation in β‐cells involves amplification of constitutive and glucagon‐activated GLP‐1 receptor signalling
por: Shuai, Hongyan, et al.
Publicado: (2021) -
γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion
por: Yu, Qian, et al.
Publicado: (2020) -
Submembrane ATP and Ca(2+) kinetics in α-cells: unexpected signaling for glucagon secretion
por: Li, Jia, et al.
Publicado: (2015) -
Glucose- and Hormone-Induced cAMP Oscillations in α- and β-Cells Within Intact Pancreatic Islets
por: Tian, Geng, et al.
Publicado: (2011) -
Glucose Control of Glucagon Secretion: There Is More to It Than K(ATP) Channels
por: Gylfe, Erik
Publicado: (2013)