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Nerve growth factor gene therapy improves bone marrow sensory innervation and nociceptor-mediated stem cell release in a mouse model of type 1 diabetes with limb ischaemia

AIMS/HYPOTHESIS: Sensory neuropathy is common in people with diabetes; neuropathy can also affect the bone marrow of individuals with type 2 diabetes. However, no information exists on the state of bone marrow sensory innervation in type 1 diabetes. Sensory neurons are trophically dependent on nerve...

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Detalles Bibliográficos
Autores principales: Dang, Zexu, Avolio, Elisa, Albertario, Ambra, Sala-Newby, Graciela B., Thomas, Anita C., Wang, Nianhong, Emanueli, Costanza, Madeddu, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560027/
https://www.ncbi.nlm.nih.gov/pubmed/31016359
http://dx.doi.org/10.1007/s00125-019-4860-y