Alleviation of exhaustion-induced immunosuppression and sepsis by immune checkpoint blockers sequentially administered with antibiotics—analysis of a new mathematical model

BACKGROUND: Sepsis-associated immune dysregulation, involving hyper-inflammation and immunosuppression, is common in intensive care patients, often leading to multiple organ dysfunction and death. The aim of this study was to identify the main driving force underlying immunosuppression in sepsis, an...

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Detalles Bibliográficos
Autores principales: Gillis, Avi, Beil, Michael, Halevi-Tobias, Karin, van Heerden, Peter Vernon, Sviri, Sigal, Agur, Zvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560115/
https://www.ncbi.nlm.nih.gov/pubmed/31187301
http://dx.doi.org/10.1186/s40635-019-0260-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560115/
https://www.ncbi.nlm.nih.gov/pubmed/31187301
http://dx.doi.org/10.1186/s40635-019-0260-3

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