Development of visual predictive checks accounting for multimodal parameter distributions in mixture models

The assumption of interindividual variability being unimodally distributed in nonlinear mixed effects models does not hold when the population under study displays multimodal parameter distributions. Mixture models allow the identification of parameters characteristic to a subpopulation by describin...

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Detalles Bibliográficos
Autores principales: Arshad, Usman, Chasseloup, Estelle, Nordgren, Rikard, Karlsson, Mats O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560505/
https://www.ncbi.nlm.nih.gov/pubmed/30968312
http://dx.doi.org/10.1007/s10928-019-09632-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560505/
https://www.ncbi.nlm.nih.gov/pubmed/30968312
http://dx.doi.org/10.1007/s10928-019-09632-9

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