CCR5 editing by Staphylococcus aureus Cas9 in human primary CD4(+) T cells and hematopoietic stem/progenitor cells promotes HIV-1 resistance and CD4(+) T cell enrichment in humanized mice

BACKGROUND: The chemokine receptor CCR5, which belongs to the superfamily of G protein-coupled receptors, is the major co-receptor for HIV-1 entry. Individuals with a homozygous CCR5Δ32 mutation have a long lasting and increased resistance to HIV-1 infection. Therefore, CCR5 represents an optimal ta...

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Detalles Bibliográficos
Autores principales: Xiao, Qiaoqiao, Chen, Shuliang, Wang, Qiankun, Liu, Zhepeng, Liu, Shuai, Deng, Huan, Hou, Wei, Wu, Dongcheng, Xiong, Yong, Li, Jiafu, Guo, Deyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560749/
https://www.ncbi.nlm.nih.gov/pubmed/31186067
http://dx.doi.org/10.1186/s12977-019-0477-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560749/
https://www.ncbi.nlm.nih.gov/pubmed/31186067
http://dx.doi.org/10.1186/s12977-019-0477-y

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