The Landscape of Phenotypic and Transcriptional Responses to Ciprofloxacin in Acinetobacter baumannii: Acquired Resistance Alleles Modulate Drug-Induced SOS Response and Prophage Replication

The emergence of fluoroquinolone resistance in nosocomial pathogens has restricted the clinical efficacy of this antibiotic class. In Acinetobacter baumannii, the majority of clinical isolates now show high-level resistance due to mutations in gyrA (DNA gyrase) and parC (topoisomerase IV [topo IV])....

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Detalles Bibliográficos
Autores principales: Geisinger, Edward, Vargas-Cuebas, Germán, Mortman, Nadav J., Syal, Sapna, Dai, Yunfei, Wainwright, Elizabeth L., Lazinski, David, Wood, Stephen, Zhu, Zeyu, Anthony, Jon, van Opijnen, Tim, Isberg, Ralph R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561030/
https://www.ncbi.nlm.nih.gov/pubmed/31186328
http://dx.doi.org/10.1128/mBio.01127-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561030/
https://www.ncbi.nlm.nih.gov/pubmed/31186328
http://dx.doi.org/10.1128/mBio.01127-19

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