Cargando…

The Landscape of Phenotypic and Transcriptional Responses to Ciprofloxacin in Acinetobacter baumannii: Acquired Resistance Alleles Modulate Drug-Induced SOS Response and Prophage Replication

The emergence of fluoroquinolone resistance in nosocomial pathogens has restricted the clinical efficacy of this antibiotic class. In Acinetobacter baumannii, the majority of clinical isolates now show high-level resistance due to mutations in gyrA (DNA gyrase) and parC (topoisomerase IV [topo IV])....

Descripción completa

Detalles Bibliográficos
Autores principales:	Geisinger, Edward, Vargas-Cuebas, Germán, Mortman, Nadav J., Syal, Sapna, Dai, Yunfei, Wainwright, Elizabeth L., Lazinski, David, Wood, Stephen, Zhu, Zeyu, Anthony, Jon, van Opijnen, Tim, Isberg, Ralph R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561030/ https://www.ncbi.nlm.nih.gov/pubmed/31186328 http://dx.doi.org/10.1128/mBio.01127-19

Ejemplares similares

Antibiotic susceptibility signatures identify potential antimicrobial targets in the Acinetobacter baumannii cell envelope
por: Geisinger, Edward, et al.
Publicado: (2020)

Author Correction: Antibiotic susceptibility signatures identify potential antimicrobial targets in the Acinetobacter baumannii cell envelope
por: Geisinger, Edward, et al.
Publicado: (2020)

A global regulatory system links virulence and antibiotic resistance to envelope homeostasis in Acinetobacter baumannii
por: Geisinger, Edward, et al.
Publicado: (2018)

Antibiotic Modulation of Capsular Exopolysaccharide and Virulence in Acinetobacter baumannii
por: Geisinger, Edward, et al.
Publicado: (2015)

Immunosuppression broadens evolutionary pathways to drug resistance and treatment failure during Acinetobacter baumannii pneumonia in mice
por: Huo, Wenwen, et al.
Publicado: (2022)

Genome-wide phage susceptibility analysis in Acinetobacter baumannii reveals capsule modulation strategies that determine phage infectivity
por: Bai, Jinna, et al.
Publicado: (2023)

Capsule-Targeting Depolymerases Derived from Acinetobacter baumannii Prophage Regions
por: Drobiazko, Alena Y., et al.
Publicado: (2022)

Prophage Induction and Differential RecA and UmuDAb Transcriptome Regulation in the DNA Damage Responses of Acinetobacter baumannii and Acinetobacter baylyi
por: Hare, Janelle M., et al.
Publicado: (2014)

A conserved zinc-binding site in Acinetobacter baumannii PBP2 required for elongasome-directed bacterial cell shape
por: Micelli, Carmina, et al.
Publicado: (2023)

A New Class of Cell Wall-Recycling l,d-Carboxypeptidase Determines β-Lactam Susceptibility and Morphogenesis in Acinetobacter baumannii
por: Dai, Yunfei, et al.
Publicado: (2021)

Correlation of Ciprofloxacin Resistance with the AdeABC Efflux System in Acinetobacter baumannii Clinical Isolates
por: Ardebili, Abdollah, et al.
Publicado: (2014)

Genomic analysis of Acinetobacter baumannii prophages reveals remarkable diversity and suggests profound impact on bacterial virulence and fitness
por: Costa, Ana Rita, et al.
Publicado: (2018)

Assessment of Biofilm Formation and Resistance to Imipenem and Ciprofloxacin among Clinical Isolates of Acinetobacter baumannii in Tehran
por: Abdi-Ali, Ahya, et al.
Publicado: (2014)

Identification of a Novel Ciprofloxacin Tolerance Gene, aciT, Which Contributes to Filamentation in Acinetobacter baumannii
por: Naidu, Varsha, et al.
Publicado: (2021)

Host Innate Immune Responses to Acinetobacter baumannii Infection
por: Chen, Wangxue
Publicado: (2020)

Acinetobacter baumannii response to cefiderocol challenge in human urine
por: Nishimura, Brent, et al.
Publicado: (2022)

Analysis of Complete Genome Sequence of Acinetobacter baumannii Strain ATCC 19606 Reveals Novel Mobile Genetic Elements and Novel Prophage
por: Hamidian, Mohammad, et al.
Publicado: (2020)

Association between mutations in gyrA and parC genes of Acinetobacter baumannii clinical isolates and ciprofloxacin resistance
por: Ardebili, Abdollah, et al.
Publicado: (2015)

Genome Sequence of vB_AbaS_TRS1, a Viable Prophage Isolated from Acinetobacter baumannii Strain A118
por: Turner, Dann, et al.
Publicado: (2016)

Database for the ampC alleles in Acinetobacter baumannii
por: Karah, Nabil, et al.
Publicado: (2017)

Strain-Specific Gifsy-1 Prophage Genes Are Determinants for Expression of the RNA Repair Operon during the SOS Response in Salmonella enterica Serovar Typhimurium
por: Kurasz, Jennifer E., et al.
Publicado: (2023)

The Capsule of Acinetobacter baumannii Protects against the Innate Immune Response
por: Akoolo, Lavoisier, et al.
Publicado: (2022)

AdeR-AdeS mutations & overexpression of the AdeABC efflux system in ciprofloxacin-resistant Acinetobacter baumannii clinical isolates
por: Lari, Abdolaziz Rastegar, et al.
Publicado: (2018)

Medicinal plant Miconia albicans synergizes with ampicillin and ciprofloxacin against multi-drug resistant Acinetobacter baumannii and Staphylococcus aureus
por: de Jesus, Genilson Silva, et al.
Publicado: (2023)

Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity
por: Zhu, Zeyu, et al.
Publicado: (2020)

Tackling Acinetobacter baumannii
por: Granata, Guido, et al.
Publicado: (2023)

Analysis of Immune Responses in Acinetobacter baumannii-Infected Klotho Knockout Mice: A Mouse Model of Acinetobacter baumannii Infection in Aged Hosts
por: Sato, Yoshinori, et al.
Publicado: (2020)

Effect of Efflux Pump Inhibitor Carbonyl Cyanide 3-Chlorophenylhydrazone on the Minimum Inhibitory Concentration of Ciprofloxacin in Acinetobacter baumannii Clinical Isolates
por: Ardebili, Abdollah, et al.
Publicado: (2014)

Evaluation of Ciprofloxacin (gyrA, parC Genes) and Tetracycline (tetB Gene) Resistance in Nosocomial Acinetobacter baumannii Infections
por: Nowroozi, Jamileh, et al.
Publicado: (2014)

Correlation between Acinetobacter baumannii Resistance and Hospital Use of Meropenem, Cefepime, and Ciprofloxacin: Time Series Analysis and Dynamic Regression Models
por: Kousovista, Rania, et al.
Publicado: (2021)

Comparative transcriptomics of multidrug-resistant Acinetobacter baumannii in response to antibiotic treatments
por: Qin, Hao, et al.
Publicado: (2018)

The Immune Response against Acinetobacter baumannii, an Emerging Pathogen in Nosocomial Infections
por: García-Patiño, María Guadalupe, et al.
Publicado: (2017)

Neutrophil and Macrophage Response in Acinetobacter Baumannii Infection and Their Relationship to Lung Injury
por: Liu, Zhaojun, et al.
Publicado: (2022)

Transcriptome Analysis of Acinetobacter baumannii in Rapid Response to Subinhibitory Concentration of Minocycline
por: Gao, Lili, et al.
Publicado: (2022)

Deciphering the virulence factors, regulation, and immune response to Acinetobacter baumannii infection
por: Shadan, Afreen, et al.
Publicado: (2023)

Multidrug-Resistant Acinetobacter baumannii
por: Abbo, Aharon, et al.
Publicado: (2005)

Multidrug-Resistant Acinetobacter baumannii
por: Krcmery, Vladimir, et al.
Publicado: (2007)

Diagnosis of Acinetobacter Baumannii Infections
por: Gozdas, Hasan T
Publicado: (2012)

Acinetobacter baumannii—The New MRSA?
por: Barrie, Alasdair, et al.
Publicado: (2016)

Glycosphingolipids Recognized by Acinetobacter baumannii
por: Madar Johansson, Miralda, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_jmeb18oakrdi9eq0esgjrevdnf