Applying causal models to explore the mechanism of action of simvastatin in progressive multiple sclerosis

Understanding the mode of action of drugs is a challenge with conventional methods in clinical trials. Here, we aimed to explore whether simvastatin effects on brain atrophy and disability in secondary progressive multiple sclerosis (SPMS) are mediated by reducing cholesterol or are independent of c...

Descripción completa

Detalles Bibliográficos
Autores principales: Eshaghi, Arman, Kievit, Rogier A., Prados, Ferran, Sudre, Carole H., Nicholas, Jennifer, Cardoso, M. Jorge, Chan, Dennis, Nicholas, Richard, Ourselin, Sebastien, Greenwood, John, Thompson, Alan J., Alexander, Daniel C., Barkhof, Frederik, Chataway, Jeremy, Ciccarelli, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561162/
https://www.ncbi.nlm.nih.gov/pubmed/31072935
http://dx.doi.org/10.1073/pnas.1818978116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561162/
https://www.ncbi.nlm.nih.gov/pubmed/31072935
http://dx.doi.org/10.1073/pnas.1818978116

Ejemplares similares