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Imaging-based pooled CRISPR screening reveals regulators of lncRNA localization

Pooled-library CRISPR screening provides a powerful means to discover genetic factors involved in cellular processes in a high-throughput manner. However, the phenotypes accessible to pooled-library screening are limited. Complex phenotypes, such as cellular morphology and subcellular molecular orga...

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Detalles Bibliográficos
Autores principales: Wang, Chong, Lu, Tian, Emanuel, George, Babcock, Hazen P., Zhuang, Xiaowei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561216/
https://www.ncbi.nlm.nih.gov/pubmed/31085639
http://dx.doi.org/10.1073/pnas.1903808116