Synapsins regulate α-synuclein functions

The normal function of α-synuclein (α-syn) remains elusive. Although recent studies suggest α-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin—a cytosolic protein with known roles in SV mobilization and clustering—is required for...

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Autores principales: Atias, Merav, Tevet, Yaara, Sun, Jichao, Stavsky, Alexandra, Tal, Shani, Kahn, Joy, Roy, Subhojit, Gitler, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561288/
https://www.ncbi.nlm.nih.gov/pubmed/31110014
http://dx.doi.org/10.1073/pnas.1903054116
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author Atias, Merav
Tevet, Yaara
Sun, Jichao
Stavsky, Alexandra
Tal, Shani
Kahn, Joy
Roy, Subhojit
Gitler, Daniel
author_facet Atias, Merav
Tevet, Yaara
Sun, Jichao
Stavsky, Alexandra
Tal, Shani
Kahn, Joy
Roy, Subhojit
Gitler, Daniel
author_sort Atias, Merav
collection PubMed
description The normal function of α-synuclein (α-syn) remains elusive. Although recent studies suggest α-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin—a cytosolic protein with known roles in SV mobilization and clustering—is required for presynaptic functions of α-syn. Our data offer a critical missing link and advocate a model where α-syn and synapsin cooperate to cluster SVs and attenuate recycling.
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spelling pubmed-65612882019-06-17 Synapsins regulate α-synuclein functions Atias, Merav Tevet, Yaara Sun, Jichao Stavsky, Alexandra Tal, Shani Kahn, Joy Roy, Subhojit Gitler, Daniel Proc Natl Acad Sci U S A Biological Sciences The normal function of α-synuclein (α-syn) remains elusive. Although recent studies suggest α-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin—a cytosolic protein with known roles in SV mobilization and clustering—is required for presynaptic functions of α-syn. Our data offer a critical missing link and advocate a model where α-syn and synapsin cooperate to cluster SVs and attenuate recycling. National Academy of Sciences 2019-06-04 2019-05-20 /pmc/articles/PMC6561288/ /pubmed/31110014 http://dx.doi.org/10.1073/pnas.1903054116 Text en Copyright © 2019 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Atias, Merav
Tevet, Yaara
Sun, Jichao
Stavsky, Alexandra
Tal, Shani
Kahn, Joy
Roy, Subhojit
Gitler, Daniel
Synapsins regulate α-synuclein functions
title Synapsins regulate α-synuclein functions
title_full Synapsins regulate α-synuclein functions
title_fullStr Synapsins regulate α-synuclein functions
title_full_unstemmed Synapsins regulate α-synuclein functions
title_short Synapsins regulate α-synuclein functions
title_sort synapsins regulate α-synuclein functions
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561288/
https://www.ncbi.nlm.nih.gov/pubmed/31110014
http://dx.doi.org/10.1073/pnas.1903054116
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AT kahnjoy synapsinsregulateasynucleinfunctions
AT roysubhojit synapsinsregulateasynucleinfunctions
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