Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity

There is clinical and scientific interest in developing local anesthetics with prolonged durations of effect from single injections. The need for such is highlighted by the current opioid epidemic. Site 1 sodium channel blockers such as tetrodotoxin (TTX) are extremely potent, and can provide very l...

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Detalles Bibliográficos
Autores principales: Zhao, Chao, Liu, Andong, Santamaria, Claudia M., Shomorony, Andre, Ji, Tianjiao, Wei, Tuo, Gordon, Akiva, Elofsson, Hannes, Mehta, Manisha, Yang, Rong, Kohane, Daniel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561913/
https://www.ncbi.nlm.nih.gov/pubmed/31189915
http://dx.doi.org/10.1038/s41467-019-10296-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561913/
https://www.ncbi.nlm.nih.gov/pubmed/31189915
http://dx.doi.org/10.1038/s41467-019-10296-9

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