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Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity
There is clinical and scientific interest in developing local anesthetics with prolonged durations of effect from single injections. The need for such is highlighted by the current opioid epidemic. Site 1 sodium channel blockers such as tetrodotoxin (TTX) are extremely potent, and can provide very l...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561913/ https://www.ncbi.nlm.nih.gov/pubmed/31189915 http://dx.doi.org/10.1038/s41467-019-10296-9 |