Overexpression of miRNA-25-3p inhibits Notch1 signaling and TGF-β-induced collagen expression in hepatic stellate cells

During chronic liver injury hepatic stellate cells (HSCs), the principal source of extracellular matrix in the fibrotic liver, transdifferentiate into pro-fibrotic myofibroblast-like cells - a process potentially regulated by microRNAs (miRNAs). Recently, we found serum miRNA-25-3p (miR-25) levels w...

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Detalles Bibliográficos
Autores principales: Genz, Berit, Coleman, Miranda A., Irvine, Katharine M., Kutasovic, Jamie R., Miranda, Mariska, Gratte, Francis D., Tirnitz-Parker, Janina E. E., Olynyk, John. K., Calvopina, Diego A., Weis, Anna, Cloonan, Nicole, Robinson, Harley, Hill, Michelle M., Al-Ejeh, Fares, Ramm, Grant A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561916/
https://www.ncbi.nlm.nih.gov/pubmed/31189969
http://dx.doi.org/10.1038/s41598-019-44865-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561916/
https://www.ncbi.nlm.nih.gov/pubmed/31189969
http://dx.doi.org/10.1038/s41598-019-44865-1

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