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The transcription factor Slug represses p16(Ink4a) and regulates murine muscle stem cell aging
Activation of the p16(Ink4a)-associated senescence pathway during aging breaks muscle homeostasis and causes degenerative muscle disease by irreversibly dampening satellite cell (SC) self-renewal capacity. Here, we report that the zinc-finger transcription factor Slug is highly expressed in quiescen...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561969/ https://www.ncbi.nlm.nih.gov/pubmed/31189923 http://dx.doi.org/10.1038/s41467-019-10479-4 |