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“Dual Disease” TgAD/GSS mice exhibit enhanced Alzheimer’s disease pathology and reveal PrP(C)-dependent secretion of Aβ
To address the question of cross-talk between prion protein (PrP) and Alzheimer’s disease (AD), we generated TgAD/GSS mice that develop amyloid-β (Aβ) plaques of AD and PrP (specifically mutated PrP(A116V)) plaques of Gerstmann-Sträussler-Scheinker disease (GSS) and compared plaque-related features...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562043/ https://www.ncbi.nlm.nih.gov/pubmed/31189938 http://dx.doi.org/10.1038/s41598-019-44317-w |